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KMID : 0377519800050010041
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Chung-Ang Journal of Medicine
1980 Volume.5 No. 1 p.41 ~ p.46
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Effects of Calcium Ion on Force Resting Relationship in Isolated Papillary Muscle of Rabbits
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Cho Yong-Moon
Cho Sung-Il
Rhee Sang-Don
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Abstract
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The effects of Ca^++ ion on forceresting relation of contraction were studied in papillary muscles isolated from right ventricle of rabbits. Isometric tension was recorded with force transducer (F50, Norco) bathing in normal Tyrode, Ca^++ 8mM/L Tyrode solution at 35℃. Control stimulations were operated as one per second and varied from shorter than control to 120 sec. Within one second, the first contractile wave after resting period increased toward control value, since then slowly decayed in normal Tyrode solution. In the first wave after resting period of Ca^++ 8mM/L, contractility expressed as percent to control value within 1 second, which proportion was same as normal Tyrode. After 10 second of resting period, percent of the first wave to control value, signifilly increased in Ca^++ 8mM/L that of normal Tyrode. The second contractile wave in Ca^++ 8mM/L increase from 10 to 40 second of resting period exhibited by first wave rather than calcium concentration. The data suggests that contractility closely relate to bathing calcium concentration within 10 second and more than 10 second resting that is appear to magnify by calcium.
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